CD163 Chromosome 12
CD163 molecule
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What This Gene Does
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Gene Info
Gene Group
"CD molecules|Scavenger receptors|Scavenger receptor cysteine rich domain containing"
Locus Type
gene with protein product
Location
12p13.31
Ensembl
ENSG00000177575
Associated Conditions (1)
Multisystem inflammatory syndrome in children
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS2136697351 | Health Risk | risk factor | Multisystem inflammatory syndrome in children, Multisystem inflammatory syndrome in children |