CAMSAP1 Chromosome 9

Calmodulin regulated spectrin associated protein 1
6 variants 6 Health Risk

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What This Gene Does
Enables microtubule minus-end binding activity and spectrin binding activity. Involved in several processes, including neuron projection development; regulation of cell morphogenesis; and regulation of microtubule polymerization. Located in microtubule minus-end. Implicated in complex cortical dysplasia with other brain malformations. [provided by Alliance of Genome Resources, Jul 2025]
Gene Info
Gene Group
CAMSAP family
Locus Type
gene with protein product
Location
9q34.3
Ensembl
ENSG00000130559
Associated Conditions (4)
CAMSAP1-related neuronal migration disorder
Cortical dysplasia
complex
with other brain malformations 12
Key Variants
All Variants (6)
RSID Category Clinical Significance Conditions
RS2491263069 Health Risk Conflicting classifications of pathogenicity CAMSAP1-related neuronal migration disorder, Cortical dysplasia, complex
RS1835459356 Health Risk Likely pathogenic CAMSAP1-related neuronal migration disorder, Cortical dysplasia, complex
RS1835535749 Health Risk Likely pathogenic CAMSAP1-related neuronal migration disorder, Cortical dysplasia, complex
RS2491269542 Health Risk Likely pathogenic CAMSAP1-related neuronal migration disorder, Cortical dysplasia, complex
RS1417914545 Health Risk Pathogenic/Likely pathogenic CAMSAP1-related neuronal migration disorder, Cortical dysplasia, complex
RS2491236071 Health Risk Pathogenic/Likely pathogenic CAMSAP1-related neuronal migration disorder, CAMSAP1-related neuronal migration disorder
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