CALCRL Chromosome 2
Calcitonin receptor like receptor
Upload your DNA to see your personal genotypes for variants in CALCRL.
What This Gene Does
Enables adrenomedullin binding activity; adrenomedullin receptor activity; and calcitonin gene-related peptide receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; cellular response to sucrose stimulus; and receptor internalization. Located in several cellular components, including endoplasmic reticulum; endosome; and lysosome. Part of CGRP receptor complex and adrenomedullin receptor complex. Implicated in hereditary lymphedema. [provided by Alliance of Genome Resources, Jul 2025]
Gene Info
Gene Group
Calcitonin receptors
Locus Type
gene with protein product
Location
2q32.1
Ensembl
ENSG00000064989
Associated Conditions (1)
Lymphatic malformation 8
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1574226259 | Health Risk | Pathogenic | Lymphatic malformation 8, Lymphatic malformation 8 |