C14ORF39 Chromosome 14
Chromosome 14 open reading frame 39
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What This Gene Does
Involved in homologous chromosome pairing at meiosis. Predicted to be located in chromosome. Predicted to be active in central element. Implicated in primary ovarian insufficiency 18 and spermatogenic failure 52. [provided by Alliance of Genome Resources, Jul 2025]
Associated Conditions (4)
Spermatogenic failure 52
Premature ovarian failure 18
Non-obstructive azoospermia
Azoospermia
Key Variants
RS748322684
Likely pathogenic
Spermatogenic failure 52, Premature ovarian failure 18, Spermatogenic failure 52
Health Risk
RS1406759691
Pathogenic
Spermatogenic failure 52, Premature ovarian failure 18, Non-obstructive azoospermia
Health Risk
RS1891315296
Pathogenic
Spermatogenic failure 52, Non-obstructive azoospermia, Spermatogenic failure 52
Health Risk
RS997282049
Pathogenic
Spermatogenic failure 52, Non-obstructive azoospermia, Spermatogenic failure 52
Health Risk
All Variants (4)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS748322684 | Health Risk | Likely pathogenic | Spermatogenic failure 52, Premature ovarian failure 18, Spermatogenic failure 52 |
| RS1406759691 | Health Risk | Pathogenic | Spermatogenic failure 52, Premature ovarian failure 18, Non-obstructive azoospermia |
| RS1891315296 | Health Risk | Pathogenic | Spermatogenic failure 52, Non-obstructive azoospermia, Spermatogenic failure 52 |
| RS997282049 | Health Risk | Pathogenic | Spermatogenic failure 52, Non-obstructive azoospermia, Spermatogenic failure 52 |