BAZ2B Chromosome 2

Bromodomain adjacent to zinc finger domain 2B
15 variants 15 Health Risk

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What This Gene Does
This gene belongs to the bromodomain gene family. Members of this gene family encode proteins that are integral components of chromatin remodeling complexes. The encoded protein showed strong preference for the activating H3K14Ac mark in a histone peptide screen, suggesting a potential role in transcriptional activation. This gene may be associated with susceptibility to sudden cardiac death (SCD). [provided by RefSeq, Aug 2016]
Gene Info
Gene Group
"PHD finger proteins|Methyl-CpG binding domain containing|Bromodomain containing"
Locus Type
gene with protein product
Location
2q24.2
Ensembl
ENSG00000123636
Associated Conditions (6)
Neurodevelopmental disorder
Inborn genetic diseases
See cases
BAZ2B-related disorder
BAZ2B-related Neurodevelopmental disorder
BAZ2B-associated neurodevelopmental disorder
Key Variants
All Variants (15)
RSID Category Clinical Significance Conditions
RS199640978 Health Risk Conflicting classifications of pathogenicity Neurodevelopmental disorder, Inborn genetic diseases, Neurodevelopmental disorder
RS2546823502 Health Risk Conflicting classifications of pathogenicity See cases, BAZ2B-related disorder, See cases
RS369373868 Health Risk Conflicting classifications of pathogenicity Inborn genetic diseases, Inborn genetic diseases
RS1296034887 Health Risk Likely pathogenic BAZ2B-related disorder, BAZ2B-related disorder
RS2149674650 Health Risk Likely pathogenic
RS2149798268 Health Risk Likely pathogenic BAZ2B-related Neurodevelopmental disorder, BAZ2B-related Neurodevelopmental disorder
RS2471337904 Health Risk Likely pathogenic BAZ2B-associated neurodevelopmental disorder, BAZ2B-associated neurodevelopmental disorder
RS2546822495 Health Risk Likely pathogenic BAZ2B-related disorder, BAZ2B-related disorder
RS2546860508 Health Risk Likely pathogenic BAZ2B-related Neurodevelopmental disorder, BAZ2B-related Neurodevelopmental disorder
RS2547061538 Health Risk Likely pathogenic BAZ2B-related disorder, BAZ2B-related disorder
RS1575883384 Health Risk Pathogenic Neurodevelopmental disorder, Neurodevelopmental disorder
RS1576949430 Health Risk Pathogenic Neurodevelopmental disorder, Neurodevelopmental disorder
RS2546859168 Health Risk Pathogenic BAZ2B-related disorder, BAZ2B-related disorder
RS780189423 Health Risk Pathogenic Neurodevelopmental disorder, Neurodevelopmental disorder
RS2547457958 Health Risk Pathogenic/Likely pathogenic BAZ2B-related disorder, BAZ2B-related disorder
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