ASMT Chromosome Y
Acetylserotonin O-methyltransferase
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What This Gene Does
This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2010]
Gene Info
Gene Group
"Pseudoautosomal region 1|7BS small molecule methyltransferases|Small molecule methyltransferases"
Locus Type
gene with protein product
Location
Xp22.3 and Yp11.3
Ensembl
ENSG00000196433
Associated Conditions (2)
Colon adenocarcinoma
Familial cancer of breast
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS148855515 | Health Risk | Conflicting classifications of pathogenicity | Colon adenocarcinoma, Familial cancer of breast, Colon adenocarcinoma |