ARMC2 Chromosome 6
Armadillo repeat containing 2
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What This Gene Does
Involved in sperm axoneme assembly. Implicated in spermatogenic failure 38. [provided by Alliance of Genome Resources, Jul 2025]
Gene Info
Gene Group
Armadillo repeat containing
Locus Type
gene with protein product
Location
6q21
Ensembl
ENSG00000118690
Associated Conditions (4)
ARMC2-related disorder
Spermatogenic failure 38
Male infertility with teratozoospermia due to single gene mutation
Abnormal sperm tail morphology
Key Variants
RS143895116
Conflicting classifications of pathogenicity
ARMC2-related disorder, ARMC2-related disorder
Health Risk
RS1562332833
Pathogenic
Spermatogenic failure 38, Male infertility with teratozoospermia due to single gene mutation, Spermatogenic failure 38
Health Risk
RS1562372417
Pathogenic
Spermatogenic failure 38, Male infertility with teratozoospermia due to single gene mutation, Abnormal sperm tail morphology
Health Risk
RS1562381747
Pathogenic
Spermatogenic failure 38, Male infertility with teratozoospermia due to single gene mutation, Spermatogenic failure 38
Health Risk
RS1562435988
Pathogenic
Spermatogenic failure 38, Male infertility with teratozoospermia due to single gene mutation, Spermatogenic failure 38
Health Risk
RS1562436860
Pathogenic
Spermatogenic failure 38, Male infertility with teratozoospermia due to single gene mutation, Spermatogenic failure 38
Health Risk
All Variants (6)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS143895116 | Health Risk | Conflicting classifications of pathogenicity | ARMC2-related disorder, ARMC2-related disorder |
| RS1562332833 | Health Risk | Pathogenic | Spermatogenic failure 38, Male infertility with teratozoospermia due to single gene mutation, Spermatogenic failure 38 |
| RS1562372417 | Health Risk | Pathogenic | Spermatogenic failure 38, Male infertility with teratozoospermia due to single gene mutation, Abnormal sperm tail morphology |
| RS1562381747 | Health Risk | Pathogenic | Spermatogenic failure 38, Male infertility with teratozoospermia due to single gene mutation, Spermatogenic failure 38 |
| RS1562435988 | Health Risk | Pathogenic | Spermatogenic failure 38, Male infertility with teratozoospermia due to single gene mutation, Spermatogenic failure 38 |
| RS1562436860 | Health Risk | Pathogenic | Spermatogenic failure 38, Male infertility with teratozoospermia due to single gene mutation, Spermatogenic failure 38 |