ARHGAP21 Chromosome 10
Rho GTPase activating protein 21
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What This Gene Does
ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]
Gene Info
Gene Group
"Pleckstrin homology domain containing|Rho GTPase activating proteins|PDZ domain containing"
Locus Type
gene with protein product
Location
10p12.1
Ensembl
ENSG00000107863
Associated Conditions (1)
Abnormal brain morphology
Key Variants
All Variants (2)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS140335265 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS1060499743 | Health Risk | Likely pathogenic | Abnormal brain morphology, Abnormal brain morphology |