ANOS1 Chromosome X
Anosmin 1
Upload your DNA to see your personal genotypes for variants in ANOS1.
What This Gene Does
Mutations in this gene cause the X-linked Kallmann syndrome. The encoded protein is similar in sequence to proteins known to function in neural cell adhesion and axonal migration. In addition, this cell surface protein is N-glycosylated and may have anti-protease activity. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"WAP four-disulfide core domain containing|Fibronectin type III domain containing"
Locus Type
gene with protein product
Location
Xp22.31
Ensembl
ENSG00000011201
Associated Conditions (10)
Hypogonadotropic hypogonadism 1 with or without anosmia
Inborn genetic diseases
Micropenis
ANOS1-related disorder
Amenorrhea
Hypogonadotropic hypogonadism
See cases
Martsolf syndrome 1
Delayed puberty
Hypogonadotropic hypogonadism 7 with or without anosmia
Key Variants
RS1043292415
Conflicting classifications of pathogenicity
Hypogonadotropic hypogonadism 1 with or without anosmia, Inborn genetic diseases, Hypogonadotropic hypogonadism 1 with or without anosmia
Health Risk
RS137852517
Conflicting classifications of pathogenicity
Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia
Health Risk
RS137879324
Conflicting classifications of pathogenicity
Inborn genetic diseases, Hypogonadotropic hypogonadism 1 with or without anosmia, Inborn genetic diseases
Health Risk
RS142455173
Conflicting classifications of pathogenicity
Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia
Health Risk
RS144709908
Conflicting classifications of pathogenicity
Hypogonadotropic hypogonadism 1 with or without anosmia, Inborn genetic diseases, Hypogonadotropic hypogonadism 1 with or without anosmia
Health Risk
RS1449749900
Conflicting classifications of pathogenicity
Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia
Health Risk
RS1930749813
Conflicting classifications of pathogenicity
Micropenis, ANOS1-related disorder, Micropenis
Health Risk
RS199771303
Conflicting classifications of pathogenicity
Hypogonadotropic hypogonadism 1 with or without anosmia, Amenorrhea, Hypogonadotropic hypogonadism 1 with or without anosmia
Health Risk
RS201842998
Conflicting classifications of pathogenicity
Hypogonadotropic hypogonadism 1 with or without anosmia, Inborn genetic diseases, Hypogonadotropic hypogonadism 1 with or without anosmia
Health Risk
RS2146807050
Conflicting classifications of pathogenicity
Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia
Health Risk
RS2229013
Conflicting classifications of pathogenicity
Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia
Health Risk
RS753666778
Conflicting classifications of pathogenicity
Hypogonadotropic hypogonadism 1 with or without anosmia, Inborn genetic diseases, Hypogonadotropic hypogonadism 1 with or without anosmia
Health Risk
All Variants (78)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1043292415 | Health Risk | Conflicting classifications of pathogenicity | Hypogonadotropic hypogonadism 1 with or without anosmia, Inborn genetic diseases, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS137852517 | Health Risk | Conflicting classifications of pathogenicity | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS137879324 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Hypogonadotropic hypogonadism 1 with or without anosmia, Inborn genetic diseases |
| RS142455173 | Health Risk | Conflicting classifications of pathogenicity | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS144709908 | Health Risk | Conflicting classifications of pathogenicity | Hypogonadotropic hypogonadism 1 with or without anosmia, Inborn genetic diseases, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS1449749900 | Health Risk | Conflicting classifications of pathogenicity | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS1930749813 | Health Risk | Conflicting classifications of pathogenicity | Micropenis, ANOS1-related disorder, Micropenis |
| RS199771303 | Health Risk | Conflicting classifications of pathogenicity | Hypogonadotropic hypogonadism 1 with or without anosmia, Amenorrhea, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS201842998 | Health Risk | Conflicting classifications of pathogenicity | Hypogonadotropic hypogonadism 1 with or without anosmia, Inborn genetic diseases, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS2146807050 | Health Risk | Conflicting classifications of pathogenicity | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS2229013 | Health Risk | Conflicting classifications of pathogenicity | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS753666778 | Health Risk | Conflicting classifications of pathogenicity | Hypogonadotropic hypogonadism 1 with or without anosmia, Inborn genetic diseases, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS755569301 | Health Risk | Conflicting classifications of pathogenicity | Hypogonadotropic hypogonadism 1 with or without anosmia, Inborn genetic diseases, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS763626643 | Health Risk | Conflicting classifications of pathogenicity | Hypogonadotropic hypogonadism 1 with or without anosmia, Inborn genetic diseases, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS773138384 | Health Risk | Conflicting classifications of pathogenicity | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS778437210 | Health Risk | Conflicting classifications of pathogenicity | Hypogonadotropic hypogonadism 1 with or without anosmia, Inborn genetic diseases, ANOS1-related disorder |
| RS808119 | Health Risk | Conflicting classifications of pathogenicity | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS990367646 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS1057519418 | Health Risk | Likely pathogenic | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS1057520209 | Health Risk | Likely pathogenic | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS1569059249 | Health Risk | Likely pathogenic | — |
| RS1601946139 | Health Risk | Likely pathogenic | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS1601988004 | Health Risk | Likely pathogenic | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS1929577517 | Health Risk | Likely pathogenic | See cases, See cases |
| RS1932981715 | Health Risk | Likely pathogenic | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS2146817108 | Health Risk | Likely pathogenic | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS2146846673 | Health Risk | Likely pathogenic | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS2518469618 | Health Risk | Likely pathogenic | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS2518500152 | Health Risk | Likely pathogenic | — |
| RS2518500156 | Health Risk | Likely pathogenic | — |
| RS932845258 | Health Risk | Likely pathogenic | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS1057520210 | Health Risk | Pathogenic | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS1064796777 | Health Risk | Pathogenic | — |
| RS1131691560 | Health Risk | Pathogenic | — |
| RS1131691863 | Health Risk | Pathogenic | — |
| RS137852512 | Health Risk | Pathogenic | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS137852513 | Health Risk | Pathogenic | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS137852514 | Health Risk | Pathogenic | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS137852515 | Health Risk | Pathogenic | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS137852516 | Health Risk | Pathogenic | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS1404298787 | Health Risk | Pathogenic | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS144586521 | Health Risk | Pathogenic | — |
| RS1555893221 | Health Risk | Pathogenic | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS1555904591 | Health Risk | Pathogenic | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS1555904596 | Health Risk | Pathogenic | Inborn genetic diseases, Inborn genetic diseases |
| RS1601965037 | Health Risk | Pathogenic | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS1602050730 | Health Risk | Pathogenic | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS1929603954 | Health Risk | Pathogenic | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS1930491968 | Health Risk | Pathogenic | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia |
| RS2146785767 | Health Risk | Pathogenic | Hypogonadotropic hypogonadism 1 with or without anosmia, Hypogonadotropic hypogonadism 1 with or without anosmia |