AMPD1 Chromosome 1
Adenosine monophosphate deaminase 1
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What This Gene Does
Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver- and erythocyte-specific isoforms, respectively. Deficiency of the muscle-specific enzyme is apparently a common cause of exercise-induced myopathy and probably the most common cause of metabolic myopathy in the human. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
Gene Info
Gene Group
Adenosine deaminase family
Locus Type
gene with protein product
Location
1p13.2
Ensembl
ENSG00000116748
Associated Conditions (6)
Muscle AMP deaminase deficiency
AMPD1-related disorder
Hypercholesterolemia
autosomal dominant
type B
Inborn genetic diseases
Key Variants
RS121912682
Conflicting classifications of pathogenicity
Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency
Health Risk
RS139582106
Conflicting classifications of pathogenicity
Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency
Health Risk
RS140181682
Conflicting classifications of pathogenicity
Muscle AMP deaminase deficiency, AMPD1-related disorder, Muscle AMP deaminase deficiency
Health Risk
RS141900642
Conflicting classifications of pathogenicity
Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency
Health Risk
RS142582318
Conflicting classifications of pathogenicity
Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency
Health Risk
RS143303736
Conflicting classifications of pathogenicity
Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency
Health Risk
RS1447749222
Conflicting classifications of pathogenicity
Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency
Health Risk
RS145786786
Conflicting classifications of pathogenicity
Muscle AMP deaminase deficiency, AMPD1-related disorder, Muscle AMP deaminase deficiency
Health Risk
RS146422068
Conflicting classifications of pathogenicity
Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency
Health Risk
RS150645738
Conflicting classifications of pathogenicity
Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency
Health Risk
RS181412206
Conflicting classifications of pathogenicity
Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency
Health Risk
RS201714031
Conflicting classifications of pathogenicity
Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency
Health Risk
All Variants (34)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS121912682 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency |
| RS139582106 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency |
| RS140181682 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, AMPD1-related disorder, Muscle AMP deaminase deficiency |
| RS141900642 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency |
| RS142582318 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency |
| RS143303736 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency |
| RS1447749222 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency |
| RS145786786 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, AMPD1-related disorder, Muscle AMP deaminase deficiency |
| RS146422068 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency |
| RS150645738 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency |
| RS181412206 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency |
| RS201714031 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency |
| RS34526199 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, Hypercholesterolemia, autosomal dominant |
| RS35859650 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency |
| RS376789465 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency |
| RS377308009 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, Inborn genetic diseases, Muscle AMP deaminase deficiency |
| RS377496676 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency |
| RS398123114 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency |
| RS398123115 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency |
| RS547487220 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency |
| RS557878856 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency |
| RS566349141 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency |
| RS570832252 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, AMPD1-related disorder, Muscle AMP deaminase deficiency |
| RS571473762 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency |
| RS61741025 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, AMPD1-related disorder, Muscle AMP deaminase deficiency |
| RS61752478 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency |
| RS61758863 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, AMPD1-related disorder, Muscle AMP deaminase deficiency |
| RS751594548 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency |
| RS770286295 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency |
| RS778223264 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency |
| RS781556684 | Health Risk | Conflicting classifications of pathogenicity | Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency |
| RS17602729 | Health Risk | Conflicting classifications of pathogenicity; other | Muscle AMP deaminase deficiency, AMPD1-related disorder, Muscle AMP deaminase deficiency |
| RS61752479 | Health Risk | Conflicting classifications of pathogenicity; other | Muscle AMP deaminase deficiency, AMPD1-related disorder, Muscle AMP deaminase deficiency |
| RS1657881990 | Health Risk | Likely pathogenic | Muscle AMP deaminase deficiency, Muscle AMP deaminase deficiency |