ALPI Chromosome 2
Alkaline phosphatase, intestinal
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What This Gene Does
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is a component of the gut mucosal defense system and is thought to function in the detoxification of lipopolysaccharide, and in the prevention of bacterial translocation in the gut. [provided by RefSeq, Dec 2014]
Gene Info
Gene Group
Alkaline phosphatases
Locus Type
gene with protein product
Location
2q37.1
Ensembl
ENSG00000163295
Key Variants
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS200403345 | Health Risk | Likely pathogenic | — |