ALG6 Chromosome 1
ALG6 alpha-1,3-glucosyltransferase
Upload your DNA to see your personal genotypes for variants in ALG6.
What This Gene Does
This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the first glucose residue to the growing lipid-linked oligosaccharide precursor of N-linked glycosylation. Mutations in this gene are associated with congenital disorders of glycosylation type Ic. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
Alpha-1,3-glucosyltransferases
Locus Type
gene with protein product
Location
1p31.3
Ensembl
ENSG00000088035
Associated Conditions (9)
ALG6-congenital disorder of glycosylation 1C
Inborn genetic diseases
ALG6-related disorder
Malignant tumor of esophagus
Renal cyst
Clear cell carcinoma of kidney
Colorectal cancer
Acute myeloid leukemia
Familial cancer of breast
Key Variants
RS1057517952
Conflicting classifications of pathogenicity
Health Risk
RS1270440540
Conflicting classifications of pathogenicity
ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C
Health Risk
RS1287725303
Conflicting classifications of pathogenicity
ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C
Health Risk
RS140158304
Conflicting classifications of pathogenicity
ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C
Health Risk
RS140879997
Conflicting classifications of pathogenicity
ALG6-congenital disorder of glycosylation 1C, Inborn genetic diseases, ALG6-congenital disorder of glycosylation 1C
Health Risk
RS145894044
Conflicting classifications of pathogenicity
ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C
Health Risk
RS146939069
Conflicting classifications of pathogenicity
ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C
Health Risk
RS1644492796
Conflicting classifications of pathogenicity
ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C
Health Risk
RS183861757
Conflicting classifications of pathogenicity
ALG6-congenital disorder of glycosylation 1C, ALG6-related disorder, ALG6-congenital disorder of glycosylation 1C
Health Risk
RS372079206
Conflicting classifications of pathogenicity
ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C
Health Risk
RS374146302
Conflicting classifications of pathogenicity
ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C
Health Risk
RS374336458
Conflicting classifications of pathogenicity
ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C
Health Risk
All Variants (141)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS2523760827 | Health Risk | Pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS2523768305 | Health Risk | Pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS2523768384 | Health Risk | Pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS2523793326 | Health Risk | Pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS2523794331 | Health Risk | Pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS2523794684 | Health Risk | Pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS752858908 | Health Risk | Pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS755112036 | Health Risk | Pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS756566938 | Health Risk | Pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS759308812 | Health Risk | Pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS773277552 | Health Risk | Pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS773699560 | Health Risk | Pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS780528545 | Health Risk | Pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS879133727 | Health Risk | Pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS1207096732 | Health Risk | Pathogenic/Likely pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS1269984067 | Health Risk | Pathogenic/Likely pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS1274913587 | Health Risk | Pathogenic/Likely pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS1471326272 | Health Risk | Pathogenic/Likely pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS1475789647 | Health Risk | Pathogenic/Likely pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS1553156884 | Health Risk | Pathogenic/Likely pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS1553157428 | Health Risk | Pathogenic/Likely pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS1644493041 | Health Risk | Pathogenic/Likely pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS1644514822 | Health Risk | Pathogenic/Likely pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS1644543791 | Health Risk | Pathogenic/Likely pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS1644562014 | Health Risk | Pathogenic/Likely pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS1644631895 | Health Risk | Pathogenic/Likely pathogenic | ALG6-related disorder, ALG6-congenital disorder of glycosylation 1C, ALG6-related disorder |
| RS1648830820 | Health Risk | Pathogenic/Likely pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS1648831627 | Health Risk | Pathogenic/Likely pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS199682486 | Health Risk | Pathogenic/Likely pathogenic | ALG6-congenital disorder of glycosylation 1C, Inborn genetic diseases, ALG6-related disorder |
| RS2100421533 | Health Risk | Pathogenic/Likely pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS2100421727 | Health Risk | Pathogenic/Likely pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS387906338 | Health Risk | Pathogenic/Likely pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS745426479 | Health Risk | Pathogenic/Likely pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS755933716 | Health Risk | Pathogenic/Likely pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS762643273 | Health Risk | Pathogenic/Likely pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS767943869 | Health Risk | Pathogenic/Likely pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS769698652 | Health Risk | Pathogenic/Likely pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS771069984 | Health Risk | Pathogenic/Likely pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS774242915 | Health Risk | Pathogenic/Likely pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS781473515 | Health Risk | Pathogenic/Likely pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS868768232 | Health Risk | Pathogenic/Likely pathogenic | ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |