ADCY3 Chromosome 2

Adenylate cyclase 3
8 variants 8 Health Risk

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What This Gene Does
This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Gene Info
Gene Group
Adenylate cyclases
Locus Type
gene with protein product
Location
2p23.3
Ensembl
ENSG00000138031
Associated Conditions (3)
ADCY3-related disorder
Inborn genetic diseases
BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 19
Key Variants
All Variants (8)
RSID Category Clinical Significance Conditions
RS139407103 Health Risk Conflicting classifications of pathogenicity ADCY3-related disorder, ADCY3-related disorder
RS369803323 Health Risk Conflicting classifications of pathogenicity ADCY3-related disorder, Inborn genetic diseases, ADCY3-related disorder
RS1668049134 Health Risk Likely pathogenic
RS1331776405 Health Risk risk factor BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 19, BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 19
RS1553329804 Health Risk risk factor BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 19, BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 19
RS1553333167 Health Risk risk factor BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 19, BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 19
RS754914420 Health Risk risk factor BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 19, BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 19
RS750852737 Health Risk Uncertain significance; risk factor BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 19, ADCY3-related disorder, BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 19
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