ADCY10 Chromosome 1
Adenylate cyclase 10
Upload your DNA to see your personal genotypes for variants in ADCY10.
What This Gene Does
The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hypercalciuria. Alternatively spliced transcript variants encoding different isoforms have been observed. There is a pseudogene of this gene on chromosome 6. [provided by RefSeq, Jul 2014]
Gene Info
Gene Group
Adenylate cyclases
Locus Type
gene with protein product
Location
1q24.2
Ensembl
ENSG00000143199
Associated Conditions (4)
ADCY10-related disorder
Familial idiopathic hypercalciuria
Reduced sperm motility
Abnormal sperm morphology
Key Variants
RS114703390
Conflicting classifications of pathogenicity
ADCY10-related disorder, ADCY10-related disorder
Health Risk
RS138171940
Conflicting classifications of pathogenicity
Health Risk
RS142478979
Conflicting classifications of pathogenicity
ADCY10-related disorder, ADCY10-related disorder
Health Risk
RS148216539
Conflicting classifications of pathogenicity
ADCY10-related disorder, ADCY10-related disorder
Health Risk
RS148603197
Conflicting classifications of pathogenicity
Familial idiopathic hypercalciuria, Familial idiopathic hypercalciuria
Health Risk
RS199931688
Conflicting classifications of pathogenicity
Health Risk
RS201804890
Conflicting classifications of pathogenicity
Health Risk
RS372120132
Conflicting classifications of pathogenicity
Health Risk
RS564897812
Conflicting classifications of pathogenicity
Health Risk
RS748513464
Conflicting classifications of pathogenicity
Health Risk
RS75116612
Conflicting classifications of pathogenicity
ADCY10-related disorder, ADCY10-related disorder
Health Risk
RS77875361
Conflicting classifications of pathogenicity
ADCY10-related disorder, ADCY10-related disorder
Health Risk
All Variants (36)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS114703390 | Health Risk | Conflicting classifications of pathogenicity | ADCY10-related disorder, ADCY10-related disorder |
| RS138171940 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS142478979 | Health Risk | Conflicting classifications of pathogenicity | ADCY10-related disorder, ADCY10-related disorder |
| RS148216539 | Health Risk | Conflicting classifications of pathogenicity | ADCY10-related disorder, ADCY10-related disorder |
| RS148603197 | Health Risk | Conflicting classifications of pathogenicity | Familial idiopathic hypercalciuria, Familial idiopathic hypercalciuria |
| RS199931688 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS201804890 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS372120132 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS564897812 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS748513464 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS75116612 | Health Risk | Conflicting classifications of pathogenicity | ADCY10-related disorder, ADCY10-related disorder |
| RS77875361 | Health Risk | Conflicting classifications of pathogenicity | ADCY10-related disorder, ADCY10-related disorder |
| RS1407377211 | Health Risk | Likely pathogenic | Familial idiopathic hypercalciuria, Familial idiopathic hypercalciuria |
| RS200044782 | Health Risk | Likely pathogenic | — |
| RS2524933602 | Health Risk | Likely pathogenic | — |
| RS751771991 | Health Risk | Likely pathogenic | — |
| RS754094260 | Health Risk | Likely pathogenic | Familial idiopathic hypercalciuria, Familial idiopathic hypercalciuria |
| RS772865627 | Health Risk | Likely pathogenic | — |
| RS996858935 | Health Risk | Likely pathogenic | — |
| RS141422393 | Health Risk | Pathogenic | — |
| RS146725782 | Health Risk | Pathogenic | — |
| RS1662641163 | Health Risk | Pathogenic | — |
| RS1663137907 | Health Risk | Pathogenic | — |
| RS1665880829 | Health Risk | Pathogenic | — |
| RS2525073526 | Health Risk | Pathogenic | — |
| RS2525194037 | Health Risk | Pathogenic | — |
| RS2526043994 | Health Risk | Pathogenic | — |
| RS576118131 | Health Risk | Pathogenic | — |
| RS747681588 | Health Risk | Pathogenic | — |
| RS757428388 | Health Risk | Pathogenic | — |
| RS763059448 | Health Risk | Pathogenic | Familial idiopathic hypercalciuria, Familial idiopathic hypercalciuria |
| RS768185604 | Health Risk | Pathogenic | — |
| RS769982899 | Health Risk | Pathogenic | — |
| RS779944215 | Health Risk | Pathogenic | Reduced sperm motility, Abnormal sperm morphology, Reduced sperm motility |
| RS865913887 | Health Risk | Pathogenic | — |
| RS770888477 | Health Risk | Pathogenic/Likely pathogenic | — |