ADAM8 Chromosome 10
ADAM metallopeptidase domain 8
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What This Gene Does
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]
Gene Info
Gene Group
"ADAM metallopeptidase domain containing|CD molecules"
Locus Type
gene with protein product
Location
10q26.3
Ensembl
ENSG00000151651
Key Variants
All Variants (2)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS141975335 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS61733287 | Health Risk | Conflicting classifications of pathogenicity | — |