ADAM28 Chromosome 8
ADAM metallopeptidase domain 28
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What This Gene Does
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. This gene is present in a gene cluster with other members of the ADAM family on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Gene Info
Gene Group
ADAM metallopeptidase domain containing
Locus Type
gene with protein product
Location
8p21.2
Ensembl
ENSG00000042980
Associated Conditions (1)
Hereditary spastic paraplegia
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS201643797 | Trait | Affects | Hereditary spastic paraplegia, Hereditary spastic paraplegia |