ABCB1 Chromosome 7
ATP binding cassette subfamily B member 1
Upload your DNA to see your personal genotypes for variants in ABCB1.
What This Gene Does
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Gene Info
Gene Group
"CD molecules|ATP binding cassette subfamily B|ATPase phospholipid transporting"
Locus Type
gene with protein product
Location
7q21.12
Ensembl
ENSG00000085563
Associated Conditions (5)
Tramadol response
Hepatocellular carcinoma
ABCB1-related disorder
Idiopathic generalized epilepsy
COLCHICINE RESISTANCE
Key Variants
RS1007307351
drug response
Tramadol response, Tramadol response
Drug Response
RS1008523470
drug response
Tramadol response, Tramadol response
Drug Response
RS1016793
drug response
Tramadol response, Tramadol response
Drug Response
RS1016975479
drug response
Tramadol response, Tramadol response
Drug Response
RS1018001117
drug response
Tramadol response, Tramadol response
Drug Response
RS1027598958
drug response
Tramadol response, Tramadol response
Drug Response
RS10276036
drug response
Tramadol response, Tramadol response
Drug Response
RS1031971223
drug response
Tramadol response, Tramadol response
Drug Response
RS1043934741
drug response
Tramadol response, Tramadol response
Drug Response
RS1046963200
drug response
Tramadol response, Tramadol response
Drug Response
RS1049335068
drug response
Tramadol response, Tramadol response
Drug Response
RS115493381
drug response
Tramadol response, Tramadol response
Drug Response
All Variants (602)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS750020655 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS751270575 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS752103700 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS753030816 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS753065601 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS754592414 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS755085099 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS755399685 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS756736504 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS756910860 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS757394498 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS758212180 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS758454815 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS759177745 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS759986853 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS761914266 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS762374613 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS762925936 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS763629745 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS764061195 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS764463583 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS766402999 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS768893111 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS769400173 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS773338757 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS776827328 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS778715012 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS779274456 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS779701045 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS780878256 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS7809208 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS781008688 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS868755 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS887308819 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS898222211 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS901502109 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS915714963 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS924572540 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS928039773 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS936689901 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS939340150 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS949343048 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS957318449 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS962879803 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS982764376 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS987724889 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS989584849 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS9282564 | Drug Response | Likely benign; drug response | Tramadol response, ABCB1-related disorder, Tramadol response |
| RS201280497 | Drug Response | Uncertain significance; drug response | Tramadol response, ABCB1-related disorder, Tramadol response |
| RS55852620 | Health Risk | Conflicting classifications of pathogenicity | Tramadol response, Tramadol response |